Genome Lab Assignment/17-Suzie

1.CCL2 (chemokine) C-C Motif ligand 2

This gene is associated with one of several cytokine genes which are a family of secreted proteins involved immunoregulatory and inflammatory process. It Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis.

2.CCL5 chemokine (C-C motif) ligand 5

This cytokine gene is one of the major HIV-suppressive factors produced by CD8+ cells.

3.ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

This gene is a member of a family of genes that provide instruction for producing the growth factor receptors. Growth factors are proteins that stimulate cell grwoth and division.

The ERBB2 gene belongs to a family of genes called (CD molecules).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other.

http://ghr.nlm.nih.gov/gene/ERBB2

Amplification and overexposure of this gene has been reported in numerous cancers, including breast and ovarian tumors.

4.NF1 neurofibromin 1

This gene product appears to function as a negative regulator, to prevent cell overgrowth by turning off another protein (called ras) that stimulates cell growth and division. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome.

http://ghr.nlm.nih.gov/gene/NF1

5.MAPT microtubule-associated protein tau

This gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

6.GH1 growth hormone 1

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control.

7.BIRC5 baculoviral IAP repeat containing 5

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death.

8. ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

This gene encodes an enzyme that plays a key role in levels of circulating enzyme or cardiovascular pathophysiologies. Pathophysiology is the study of the changes of normal mechanical, physical, and biochemical functions, either caused by a disease, or resulting from an abnormal syndrome.

My favorite gene in the sequence is the GH1 because it is a growth hormone important in growth control. I did not know there was a gene for this. The birth of the body is an amazing complex miracle. The intelligence in the dna and the genes, is almost unfathonable.